The Mutation Station combines the physical with the virtual, giving museum visitors power over the code of life. Located at the heart of the exhibit The Genomic Revolution, this interactive invites visitors to use a floor to ceiling electronic sculpture to change the DNA of a fly. On a large 50” plasma screen looms a fruit fly with its DNA splayed out beside it. Corresponding exactly to the graphic DNA on screen, the electronic sculpture of DNA gently swirls to the ceiling with its illuminated representations of the nucleotides. The visitor is invited to physically turn the rungs to search for a point mutation. When a mutation is found, the fly animates to its mutated form. The computer then loads a new sequence of fly DNA which cycles through both the screen and sculpture until it stops where a new mutation can be found. The interface for this interactive is unlike any other. It’s an electronic sculpture designed for visitor input. Though the interface is unusual, it’s also intuitive, simple, and easy for visitors to use. Strengthening the visual connection between sculpture and screen, is a rich layer of audio constantly giving the visitor feedback in response to what they have done and the status of the interactive. Collectively the Mutation Station’s physical elements combine with the virtual, paving the way for a new vocabulary and expectations from the public.